It is possible that some kind of contaminate got into the water during your last water change, although if the other frog is fine, that's probably not the case. Nematodes are the type of thing that a Xenopus frog can have it's entire life and not be affected until it is stressed for some reason. If there is no bleeding, ulcers or redness, then it is probably not a bacterial disease. I would try isolating the animal and adding some aquarium salt to the water. This causes them to shed and therefore rid themselves of external parasites etc. If the frog is swimming around rapidly then it is in pain or extremely agitated, as they are usually very sedentary. Do you have a pic?

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