"How long will a baby tegu last in a 75 gallon tank?"
I can't really answer that question definitely. Maybe CrimsonWolf can help. I'm assuming that you are referring to a larger Argentine B/W tegu...He might be able to last in there the first year. If you are purchasing now, then you likely have a baby that hatched at the end of last summer. I have one of those hibernating right now and he's still pretty small and green. When he wakes up, though, he's going to eat like a horse and grow like a weed. Tegus are pretty active and need a lot of room to move around. By the time he hibernates next Oct/Nov, I'm sure he'll be at least 2 ft long. A ft tegu in a 75 gal might be tight squeeze.

"What type of substrate is good?"
I like to use Cypress Mulch. It's pretty easy to clean, but it can be a little messy. It holds humidity well when it's misted and the tegus like to bury down in it. It's cheap, and I can pick it up at Home Depot.

"What type of fluorescent lights are required? Can the fluorescent lights purchased at Home Depot suffice? I will be using a outside flood lamp for heating purposes."
Hmm...I think you are referring to the full spectrum lights at Home Deopt. Nope, they do not have enough UVB output. I would look for a Repti-Sun 5.0 bulb and change it every 6 months. I put the long bulbs in a fixture I buy from Home Deopt, but I don't use the HD bulbs.
The other option is a Mercury Vapor bulb. They are a little more expensive, but combine heat and UV. I'm not sure I would use in a 75 gallon, but in a larger enclosure.
As for your heat, check the wattage and heat output of the flood light. I use standard soft white bulbs for heat. You don't want too bright light for your lizard nor too much heat.

Enjoy your little friend!

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