I actually like the zoo med burrowing substrate, I don't find that it is too dusty. I do mist the cage every week or so to keep the humidity up some, so this may also keep the dust down some. The water drains to the bottom most part and the surface dries out very quickly, so there is never really standing water in the cage. Contrary to popular opinion, uromastyx do need some humidity. Improper shedding will also lead to serious skin problems. It is very hard for me to get any humidity in open top aquariums with the high temps necessary to properly maintain desert species. Adding water to a closed cage (vision type cage) might raise the humidity too high.
I mix about 1/2 filter sand and 1/2 of the substrate for the top 1/4 inch or so and add a lot of large/medium size rocks to the mix. You can vacuum out the feces with a hand held vacuum cleaner. Sand or sand mix on top makes it a little easier to clean.
I have also used sand and large "chunky" aquarium gravel along with large pieces af slate and tile. Sand is easy to clean, and if you use the vacuum method so is the rock. My problem is that they don't hold any humidity well and my uro was having some shedding issues. I think a more solid substrate is better they don't seem to walk "normal" on loose substrate like sand or bird seed.

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