A few hognose bites have resulted in dramatic symptoms (at least for a species widely regarded as completely harmless), including extensive swelling, tenderness, and pain. A case study was presented at Venom Week 2009. The symptoms occurred too quickly to have been caused by bacterial infection, but resolved on their own sometime later. The species in question, H. nasicus, is generally quite inoffensive (the only real bites I know of were feeding related), and I don't think they should be considered as anything other than "relatively" harmless. Certainly not an animal warranted to be considered venomous by any legal standard, though by a biological definition, they most certainly are.
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Abhishek Prasad

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