Doug,
In response to your earlier question, there have been reports of tissue damage or necrosis at the site of injection when using Baytril with reptiles. Sometimes it will cause problems and then sometimes not, however it is a risk. I have heard of the procedure you described in your post to help minimize the damage and it does help. Another option which appears to work even better is to not only keep the volume of any injection site at 1cc or less as in your post, but to also dilute the injected Baytril to 50% before hand to lower the concentration as well. The total dosage of the Baytril is unchanged, but just spread out so as not to be as concentrated in the tissue. For example, instead of injecting 1cc of Baytril at one site on the animal, dilute the concentration by half with sterile water for injection, and then you will be injecting 2cc of solution, 1cc at each of two sites on the animal. This lower concentration of Baytril at each injection site seems to help to avoid the tissue damage. Just make sure that you use the actual product of sterile water for injection to make these dilutions.

On the dosage regimen for Baytril, the initial double dosage of 10 mg/kg is called a loading dose and is safe when using Baytril as it is relatively non-toxic and has a pretty good margin of error regarding toxicity. This is done to obtain a rapid and high initial serum concentration of a given medication, and then falling back to the standard dosage for all subsequent dosages. Loading doses with aminoglycoside antibiotics for example, like gentamicin, amikacin, and tobramycin would be of more risk due to their increased toxicity and in those cases a lot would depend on the actual species being treated.

Kelly

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