Most of the care books for ball pythons tend to recommend that you don't handle them more than 15 minutes in a week. They say it could potentially stress them out and throw off their eating. I would think if your snake isn't taking the threatened posture and balling up your company isn't bothering it and it is probably OK to handle it more but if it is being scared I wouldn't force interaction on it too much until it gets a little more confident.

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