I need to know a few things... when did you set up your tank? what are the water parameters? Do you only have one koi in the 46 gallon tank? Without knowing anything but what size the tank is and your symptoms, I would say either your tank is cycling or your ammonia is too high (or a combination of the two).
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Phishie
Site Coordinator

"An ounce of prevention is worth a pound of cure."

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