It sounds as if the male is "blaming" the vet trip on the female. Of course she's confused! You should definitely keep them separated for at least two days with no contact with each other. During that time rub one then the other with a towel to exchange scents. Also it will help if you get a Comfort Zone plug-in with Feliway. This will help calm the male. You can gradually re-introduce them, but as soon as the hissing starts, separate them again. It is also helpful to have the cats exchange territories for a while - in other words put the male in the guest bathroom for a while and let the female roam the house then put the female in the guest bathroom and let the male roam the house.

Since you do have company coming soon, you might want to talk to the vet about prescribing some anti-anxiety meds for the male. Usually these are a last resort type thing, but you are up against a time constraint and also the company will stress the cats more.

Usually when anti-anxiety meds are used with cats, the cat "unlearns" the behavior and the meds can be tapered off and gradually completely discontinued.

Good luck!
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Smile, it will make them wonder what you are up to!

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