This is something that you probably should discuss with your vet. Ordinarily tranquilizers for cats are not recommended for long trips because they are unreliable. However, there may be something that can be done.

Also you should have a long talk with the airlines. If warned ahead of time, special handling can be requested. Also you might be able to take the cat as a carry on, although with overseas flights this might not be feasible.
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Smile, it will make them wonder what you are up to!

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