Sudden changes in urinating behaviour always warrant a vet visit as they can indicate a urinary tract infection. To pee outside the box is one way of a cat to communicate to you that something's wrong.

After she has a clean bill of health you can think about other possible causes - stress, boredom, intimidation etc. Locking them out of your room could actually aggravte the problem as it would add stress for the cat.

First have her checked out, please, and tell us what the vet said.

Thanks and good luck!

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