Many times when they have been separated, such at the vets, when they are re-united the scent that they were familar with is not there so they hiss and growl. You will probably need to keep them separated and re-introduce them again. I have never had a problem with any of my cats going outside the box but you might try this. Put some paper down around the box so that the next time she goes outside the box, the paper gets wet. Take a little piece of the paper that she has urinated upon and put it into the box. Maybe the scent will attract her to the box. It may take a few tries but sometimes it works. I am sure that others will have more suggestions.
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Boris's Human, Pam

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