What works well with leopards works with fat tails as far as substrate goes. The above posts made some good suggestions; I personally use dry top soil with my leopard (don't have fat tails)
As far as humidity goes, it is naturally more humid in the hide box, so as long as you provide one and mist it occasionally (perhaps put some moisture retaining substate in there, like moss) your gecko should do great. These are dry scrubland type lizards, so the entire enclosure should not be humid.

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