I encountered these "pimples" a few years back on some geckos I kept in a small vivarium. I did some research and learned the following.

They are normally a bacterial infection caused by a too-moist environment, and occur in all sorts of reptiles. Normally, if you catch it early and reduce the moisture in the environment, the infection clears naturally. Any remnant of the pimples is normally gone with the next shed. (I emphasize the "normally's" because bacterial infections can be unpredictable and serious, as the experience of the other respondent shows.)

The danger to the lizard posed by this infection can depend on the severity of the infection and the size of the lizard. A U. henkeli can probably recover OK, but a little phelsuma could be more easily overwhelmed by the infection.

I'm no expert but this is what I remember from a few years ago.

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