As I i was told almost 10 years ago you should be able to go seven generations in before you start getting physical genetic problems. This opinion has changed in the past ten years from one breeder to another and also from one scientist to another. In reptiles there is a more diverse gene pool then human so inbreeding does not have the same limitations as it does in humans. The F1 as I was told is the original offspring from the original parent. The when you breed those offspring together you get F2 and so on and so forth. The Hypo genes are the perfect example of how inbreeding can work well to achieve a better expression of that gene.

Of course if you take the finest example of the hypo gene in when it reaches F7 and go to an unrelated animal you will have F1's from your F7 line.. From there I would need to read up on how this addressed by the number's. Howver you would be able to go another seven generations to keep refining the gene.

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