Scale rot generally comes from poor husbandry such as unwarrented/excessive soakings and maintained levels of high humidity.
Remove substrate and replace with clean"aged" newspaper
Use regular Neosporin* twice a day for a week or so and check results.Do not try and remove anything(scales,skin etc.) from affected area.
Keep humidity levels down around 45-50%,feed as usual.Next shed should remove affected area.

Plenty more can be said but here is a place to start.

Good Luck!

M/

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