Here's the difference in my experience: Many balls that are on pre-killed food will only eat pre-killed and reject f/t. So if one week that snake is not hungry and you freeze the pre-killed rat to try later, the snake will probably turn it's nose up at it when it's f/t.
I had nearly all my snakes on f/t and I loved it because it was so cheap, but then I decided to start breeding some of my own rats (which I would then pre-kill). The problem is that 1/3 of my collection decided they preferred pre-killed over f/t and I don't always have the right sized live rats available for them.

If you only have a couple snakes, f/t is the most convenient because it's cheaper, and you can always re-freeze once and try again a week later if you have a picky eater. Pre-killed is more expensive (since you're buying live), but if you have a ton of snakes then the odds are that if a snake is picky one day, you can just turn around and offer the prey to another less picky snake.

Also, freezing for one month kills most internal parasites and bacteria.

~kasey

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