I've seen a lot of people stress handling the snakes often. Here's my two cents:

I bought an adult snake that would freak out when you hold it. It would thrash, flatten its body, try to get away... If it sniffed my skin while I was holding it, it would turn the other direction and take off. I handled that snake once a month only for several minutes (hey I was working out of town). Even with that little bit of handling, he got used to me. Now I can grab him out of his hide and put him around my neck and he's calm as can be.

Oh - and be wary around feeding time. Most pythons have heat pits and a warm hand moving near their head may invoke a bite. It's just a reflex and it happens with the tamest of snakes.

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