Where you thinking of different "normal" alleles of the same gene as the mutation or genes at totally different locations than the mutation?

I could see either coming into play.

But particularly with mutations that have problems in the homozygous form if there are multiple normal looking versions of that gene I could see the problems sometimes coming through in the heterozygous animals if there are some normal alleles that don't compensate as well as other normal looking alleles.

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