As long as he looks otherwise healthy and temps etc are good, I'd guess that he's getting ready for breeding.

You may be able to get him started feeding by giving him a different food item (like maybe a live rat pup), or changing his surroundings (like give him a hide, or minutely adjust humidity/temps). Most of all, don't stress unless he looks sick or is really losing weight. He'll come around, but it could be a while.

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