This is strictly my opinion because I am not overly familiar with the toxicology of Fipronil, the active chemical in Frontline. It is appears to be not overly toxic to mammals, but is highly toxic to insects, fish and many bird species. It is a potent central nervous system disruptor in affected organisms. I have not seen any toxcity data for reptiles, but my guess would be that it would be too toxic to use on reptiles. Mammals appear to be the only taxa were the toxcity is relatively low based on their CNS chemistry. Good question.

Kelly

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