I think something also needs to be said about which gene it is. Some are much stronger than others from the start. If you look at ball pythons(only because there is way more genes to play with) you can see problems with them.

Spiders wobble and they don't have to be inbred for them to express it. Caramel albinos kink bad when they are inbred, super cinnies duckbill. The big breeders didn't have anything to say until it was so widespread that they couldn't hide it anymore.

The genes we breed for are usually just abnormalities that we like. Sometimes this weakens the genetic ability of the animal and sometimes it doesn't.

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