Posted by:
WW
at Wed Dec 10 04:33:55 2003 [ Email Message ] [ Show All Posts by WW ]
>>PHOSPHOLIPASE A - Promotes histamine production in tissue. Also probably largely responsible for the "shock factor" encountered in snakebite. (S/E: Black Mamba, Taipan, cottonmouth)
Whoever wrote this needs to do their homework a bit better. PLA2 toxins cause a number of effects, in particular presynaptic neurotoxicity and myotoxicity. I don't know whetehr they are involved in histamine release and shock at all - I certainly can't recall reading that anywhere, and suspect that different toxins are involved in those processes, but am happy to be corrected.
Mamba venoms contain very little PLA2, in fact, we seem to have been the first to demonstrate that they are there at all in our colubroid LCMS paper (see link below).
Cheers,
Wolfgang
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