Posted by:
WW
at Wed Dec 10 04:33:55 2003 [ Email Message ] [ Show All Posts by WW ]
>>PHOSPHOLIPASE A - Promotes histamine production in tissue. Also probably largely responsible for the "shock factor" encountered in snakebite. (S/E: Black Mamba, Taipan, cottonmouth)
Whoever wrote this needs to do their homework a bit better. PLA2 toxins cause a number of effects, in particular presynaptic neurotoxicity and myotoxicity. I don't know whetehr they are involved in histamine release and shock at all - I certainly can't recall reading that anywhere, and suspect that different toxins are involved in those processes, but am happy to be corrected.
Mamba venoms contain very little PLA2, in fact, we seem to have been the first to demonstrate that they are there at all in our colubroid LCMS paper (see link below).
Cheers,
Wolfgang
WW publications available online
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[ Hide Replies ]
- Venom questions for the experts - budman 1st, Tue Dec 9 16:55:03 2003
- Mirror,mirror - Deuce, Tue Dec 9 20:41:40 2003
- RE: Mirror,mirror - budman 1st, Tue Dec 9 21:39:58 2003
- ok whats what? - budman 1st, Tue Dec 9 21:43:43 2003
- RE: ok whats what? - Deuce, Wed Dec 10 08:41:12 2003
- cool - budman 1st, Wed Dec 10 16:51:54 2003
- RE: cool - nobites, Wed Dec 10 17:42:39 2003
- ok - budman 1st, Wed Dec 10 18:32:07 2003
- more - budman 1st, Wed Dec 10 18:53:08 2003
- true, but.. - nobites, Wed Dec 10 22:15:41 2003
- and - budman 1st, Thu Dec 11 04:08:52 2003
 RE: Venom questions for the experts - WW, Wed Dec 10 04:33:55 2003- RE: Venom questions for the experts - BGF, Wed Dec 10 21:24:26 2003
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