I would say any of the above are good. I personally like single piece substrates because I think feeding is a bit easier that way. I have heard something wrong with paper towels and I honestly cannot remember what it was. Maybe something to do with bleach. I would like someone else to comment on that because Bounty has some really nice quilted towels now that are very strong. I think cleaning would go a lot easier if I used them and I would not have to deal with ink when they get all wet. Only downfall I see is spot cleaning is a bit more thorough since you are replacing most or all of the substrate each time. You are also likely to get more humidity with vypress mulch. I have never had a problem with humidity in a rack though and I use newspaper. If anything I work to keep it down.

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