I would not use Plexiglass unless you have breakage concerns with an active dog, young child, etc. Plexiglass and other acrylics are too susceptible to yellowing, warping and scratching.

If you have an idea for a mesh/pvc tubing cage, then by all means build that if it's what you want. I guess the one thing I'd emphasize is that if you have vision of what you want, then try to build that. There are few reptile cage designs that I would describe as difficult to build.

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