I don't have any experience building a cage that large with Sintra or any other brand of expanded PVC. I do have some experience with it, however. One of the regular posters on this forum will be very helpful with the larger cage construction.
I have no doubt it would be able to withstand the daily mistings. The only reason it's rated for indoor use only is because it is not extremely UV resistant, which won't be a concern even with the most powerful mercury vapor bulb. I'd be more concerned with its ability to withstand scratching, depending on the species of tree monitor.
Celtec 550 is one expanded PVC product that is rated for incidental food contact, suggesting it is somewhat safe. It is also one of the lightest PVC sheet products if not the lightest. But I'm sure at least part of your cage will be quite warm for a tree monitor so that may affect things, I don't know.
Back to the size of your cage, will you be able to fit that through doors, around corners, etc? The walkout basement of my home was built to be handicap accessible and I could not fit a cage that size into anywhere but two large entry rooms in my house.
Also, I want to warn you that if you go with a thicker expanded PVC product due to the size of your cage that you may very well end up with a heavy cage. Many people buy 1/2" expanded PVC since it's easier to work with and stronger and are surprised to find out it often weighs more than 1/2" plywood.
Just to give you an example, the 1/2" Celtec 550 I have out in the garage weighs 43 lbs. per sheet, or 1.35 lbs. per square foot. And it's the lightest 1/2" sheet material I could find.
1/2" baltic birch plywood is 1.72 lbs. per square foot and that's about the heaviest plywood you can find. So a 4x8 sheet of it would weigh 55 lbs.
Some 1/2" expanded PVC products weigh over 70 lbs and some 1/2" plywood weighs less than 50 lbs. So be careful if weight is important. Or figure out a way to use 1/4" material.
I think expanded PVC is a great material for cage construction but it does have its limitations. If I absolutely needed a cage that size I would build it from those aluminum tubing connectors and use a 1/4" plastic material. That way the cage could be taken apart once a silicone seal was scraped away.
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Current snakes:
0.0.1 Gonyosoma oxycephala - Java locale (green)
2.2 Gonyosoma janseni - Seleyar locale (all black)