A lot of breeders, myself included, have been faced with this for many years. I had horrible numbers of babies going full term and then die before they pip. I was speaking to a close friend of mine who is a veterianarian and he told me it may be a problem with calcium deficiencies in the female producing the eggs. I supplemented my females and did have much better results with hardly any babies going full term, then dying in the shell. I reported this in a couple of the trade magazines. Many people supplemented there animals with calcium and had problems with their adults. These problems included enlarged hearts. That kind of made me reduce supplementation. I again started having full term babies die in the shell....
Personally, I do not know if perlite will help. That is something I also tried with poor results in the early 1990's. Another friend of mine told me this summer that when he was working at a zoo in Texas, they had similar problems. He felt placing a damp paper towel over the eggs one week prior to hatching would soften the egg shells allowing the baby snakes to have better success pipping. I am trying this strategy this year.....I should point out, alterna are the only snakes I have these problems with for the most part. I have success hatching out pyromelana, hognose snakes, California kingsnakes, Mexican Milksnakes, corn snakes, and on and on....anyway, placing a damp paper towel on the top of the eggs one week prior to hatching seems like it would be an easy fix. What are everyone else's thoughts! Thanks......