Yup- I just did the same with my southern pine, olive python and bredli python from San Diego, CA to Austin, TX.
I got some good advice from the regulars on this forum.
We took the LONG route with 3 kids, 3 dogs, 3 snakes and wife, so it actually took us 3 nights in hotels before we finally reached 'home'.
I got myself the largest cooler I could find to fit 2 shoebox sterilites and a 15qt sterilite (olive python). Lined each of them with aspen shavings, taped the tops shut, gave each of them plenty of air holes, and had a thermometer inside the cooler so I could check temps.
They rode shotgun with me the whole way, and I probably checked the temps on them every 15-20 minutes. (I was REALLY paranoid)
The were absolutely fine. When we stopped to grab a bite, I'd make sure the lid on the cooler was shut good, and that we weren't away too long. Everytime I'd get back to my car, I'd open up the cooler and check the temps- they barely moved.
The biggest thing you want to make sure of is that they don't overheat!
Every night in the hotel, I'd give each of them a bowl of water, and find a nice spot for them to chill away from the dogs.
Good luck to you on the move!
//Todd