it would be helpful to know what type of cage, age of cham, how long have you had it, what do you feed it, how do you gutload your feeders, how do you measure your temps, humidity, do you use supplements?
Go to link below and look under Tips section for other Q&A which might be helpful.
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Chameleon Help & Resource Info
1.0 Nosy Be Panther Chameleon - Cyrus
0.1 Veiled Chameleon - Luna. She's now hanging from her big jungle gym in the sky
1.0 Beardie - Darwin
1.1.1 Side-blotched lizards - Ana and Stan
0.2 felines - Kyndra and Lita
0.1 African Clawed Frog - Skippy
0.1 Chilean Rose Hair Tarantula - Rosa Leigh, Died 4/21/06 
0.1 Goliath Bird-Eater Tarantula - Natasha, donated to science 4/4/06
?.? Pinktoe Tarantula - no name yet