Where the term comes from - every gene pair has one gene from each parent. Very often defective genes are recessive - as recessive genes can hide from natural selection in heterozygous gene pair and be passed on, where dominant genes can not.
When you breed two species, some defective genes from each parent may be passed on, but since the species have split some time ago, there is a really reduced chance that the same defective gene exists in both species.
This is only the case with F1 hybrids. F2 hybrids, especially line bred, do not have the same protection against a homozygous defective gene pair.
This is the same reason why outcrossing lines of same species reduces the expression of defective genes. F1 of my WC cal king and an amel cal king, none of the neonates express the defective gene responsible for amel albinism - but line breed them to produce F2 and 1/4 of the young will in fact express that defective gene.
But if I take those F1 and cross them with, say, scissor crossing - none of the young will express the amel gene, and only half of the young would carry the gene meaning any line bred pairing from that outcross only has a 25% chance that both carry the defective gene, so there's a real good chance such a pairing would not produce any that express the defective amel gene (though it may be present in some of the young).
I have to wonder if some of the reported fertility problems in several generation hybrids are actually the result of line breeding rather than the hybrid process, and if every 3 generations or so - getting unrelated but same hybrid mates would result in better fertility.
But the "hybrid vigor" effect doesn't guarantee better young, as there may be some gene pairs that just don't work the way they are suppose to. It took many attempts at Bison and Cattle before they could get Beefalo produced that were not sterile.
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3.6 L. getula californiae - 19 eggs (Cal. King)
1.1 L. getula nigrita (MBK)
1.0 Pantherophis guttatus guttatus (Corn)
0.1 Pituophis catenifer catenifer (Pacific gopher)
3.3 Elgaria multicarinata multicarinata (Cal. Alligator Lizard)