Generally inbreeding should be avoided if at all possible.
Every individual animal is born with a diverse genome. Most contain some mistakes and weak points, as well as unique sequences that fight viruses and maintain all other bodily functions. By breeding closely related animals you loose some genetic diversity and you increase the risk of amplifying any weaknesses, mistakes, or mutations.
Problems don't usually appear from the first generation (although they can). But if done for several generations without any outbreeding, the line will eventually fail completely.
When you have unique traits, sometimes you need to inbreed to reproduce them, but any good breeder should also outbreed the trait to get hets and ensure that his bloodline stays vigorous and healthy.
If you can, I would recommend getting another pair and switching them. That would give you two unrelated bloodline when you go to sell them as well. Or trade one of your current snakes for an unrelated one of the same sp.
If you do breed the siblings its not the end of the world, but I would be especially careful not to sell the offspring as "pairs" to someone else who is going to do the same thing. Thats how weird deformities start.