I agree with Ian. While herps are not as inbred as our domestic dogs and cats, where purebred animals commonly suffer from hereditary disorders, it is ignorant to think that this cannot occur in other species.
We are already seeing effects of heavy inbreeding on species like Bearded Dragons (Pogona vitticeps), Leopard Geckos (Eublepharis macularius) and potentially Cornsnakes (Elaphe guttata).
Good beardie breeders will provide bloodlines to avoid inbreeding, because inbred beardies are doing very poorly at this point. There is plenty of anecdotal evidence that inbred beardies have very poor immune systems and do not fare well.
I've heard many suggestions that the more whacked out, inbred Leopard Gecko lines like SHTCTs, APTORs and RAPTORs are more susceptible to cryptosporidiosis. I've even heard some discussions that crazy Cornsnake morphs that are very inbred may be more susceptible to crypto.
At this point, there is only anecdotal evidence and no scientific studies to back these claims up. But considering the massive inbreeding that occurs to mix, match and discover new colour and pattern mutations, this idea is not far-fetched.
What degree of inbreeding is risky or unacceptable is uncertain, but the heavily captive-bred with many mutations are certainly on the top of the list. Dogs and cats have hundreds of years of inbreeding for wacky mutations behind them, herps have only a few decades. But consider shorter gestation/incubation periods compared to domestic mammals and a few decades may be a bit longer than it seems, generation-wise.
We are on the cusp of needing to be cautious with inbreeding our heavily bred pet species. With other, less common species, sometimes we have so few healthy specimens that inbreeding is inevitable, and with only a few captive-born generations there probably won't be any ill effect.
Also keep in mind that careless, irresponsible breeders that inbreed heavily are also likely to be the ones who are not stringent with husbandry.
Overcrowded animals are stressed, and stress is bad news to herps. Poor maternal nutrition means poor amniotic nutrition and weak offspring. Sub-optimal incubation temperatures will also risk problems.
There are so many factors, that when you have a young, hotshot "breeder" whose Leopard Geckos bred by accident and s/he's claiming that everything he's doing is absolutely correct and the ideal, then take that advice with a grain of salt!
Christina
www.herptiles.net