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I just got another male Jackson's and on its rear foot it has a lump about the size of a large pea.... it looks like it's toes on one side got a nail ripped out or something and it just ballooned up... I need help with this. I'm not sure what to do. He is feeding like crazy still and doesn't seem to be stressed at all..... any help would be greatly appreciated, thanks a lot i also have more pics i can email.... i cant figure out how to post more than 1 on here

You need to take it to a vet so that the infected area can be cleaned out and the chameleon put on antibiotics. If you don't get it treated the bacteria will likely go throughout the body and kill the chameleon.

The vet will need to do a culture and sensitivity test of the material removed from the area.

Yep, that's a pretty nasty infection going on there. Chams are tough and try not to react to a problem so they don't appear vulnerable to a predator (that's why he's eating and behaving "normally". You will definitely need a vet to open this up. As kinyonga said, the infection could be systemic now and the vet will need to do a sensitivity test to determine what antibiotic will be effective. Many vets just default to using Baytril without doing a sensitivity culture but Baytril can be very tough on kidneys. A better vet will clean the thing out, start a topical antiseptic/antibiotic, while the culture is processing, possibly start a milder broad spectrum antibiotic until the culture results come in, then start the most appropriate treatment. Treating it with a surface antibiotic alone won't do it at this point. Until you can get to a vet you could gently scrub it with Betadine and put some Polysporin on anything that looks like an open sore, but it may only slow the infection down a little and ease the pain. It's got to hurt!