A.J.,
For the typical 28 to 32 quart sweater box, the design of the rack and materials used probably does not matter as much unless you're keeping really good escape artists, like small Milk or Kingsnake species.
Normally when I build a sweater box rack I make it so the 28 qt. boxes slide in width wise. Then I can use two 12 qt. boxes from the same company and fit two of them per level that slide in lengthwise. I'm not sure I would attempt this with PVCX, although it clearly can and has been done. I just don't know if it's the best idea. I have heard of a few people who ordered professional racks of this design and they have complained that the boxes sieze slightly after a year or so. In some cases the boxes siezed but the gap in the middle front of a level got larger. Enough so that not any old snake could be placed in that level.
The upshot is - if you don't need the smaller, half-sized boxes I would recommend having the boxes slide in length-wise, therby making everything more sturdy.
Regarding the weight of expanded PVC, weights are ALL over the place. As I have posted before, 1/2" PVCX can be HEAVIER than 1/2" plywood and close to the weight of 1/2" melamine. If you shop carefully, however, you can buy 1/2" PVCX that is quite a bit lighter than 1/2" plywood.
I researched this topic quite a bit two years ago and the lightest of the most readily available brands of PVCX was Celtec 550 (ironically, Celtec also makes one of the heaviest). I can't say if this is still the case today.
If weight is important to you I would shop carefully. I have had a large handful of people take advice on building with PVCX but have ended up disapointed with the final weight of their project.
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Currently keeping:
6.10 Gonyosoma oxycephala (Javan, mixed colors)
1.1 Philodryas baroni
1.0 Rhodesian Ridgeback