I would be inclined to think it's environmental more than anything. What type of enclosure are you using? What is the temp gradient? Ambient RH? Is the moist hide in the enclosure at all times? What type of substrate?
Also, do you keep FRESH water available at all times? Some folks simply add to the existing water in bowl, without thoroughly cleaning the bowl and replacing all the water. Internal hydration is as important (if not more) as external moisure/hydration. My carpets are kept with humidity at about 30-40%, which is somewhat low, but it is the average humidity in my home. With proper internal hydration, I rarely, if ever, encounter any shed problems.
The only time I really do any misting is usually during the breeding season.
Good luck!

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"He who would stifle debate rather than engage in it, does so at the expense of his integrity and credibility"
Mike Curtin