Reptile & Amphibian Forums

Hey folks,

Is the appropriate dosage of Tylan 200 for a 12lb. boa 1.4cc?

Thanks.

50 mL / Kilogram . . . . . .

Tylan 200 dosage = .025 ml or cc

So for a 12 pound Boa yes 1.4cc ( 1.4mL )

If the the Tylosin doesn't work try Antibiotic - Liquamycin - LA-200 . . . . . Dosage 1.00 cc for every 10 pounds of Boa . . . .
Inject Boa ever 3rd day.

. . . Lar M
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Boas By Klevitz

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Kelly Haller's post March 5 2010- her dosage is 20mg/kg/48hrs- 12lb boa = 4.4kg , 4.4 x 20=88mg. Tylan 200 is 200mg/ml wich would mean that you would want 0.44ml.
She is talking about treating an RI, is that what you are treating or are you treating something different. if so, is that why you'r dosage is higher?
I am just curious student, thanks for any future information
Rob

excuse me 5.4 kg -making it 0.54 ml

Not sure of the dosage, but Kelly Haller is a man...

~Doug
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"a snake in the grass is a GOOD thing"

serpentinespecialties.webs.com

Based on a 50mg/kg dose, I arrived at 1.4cc.

You have calculated the correct dosage of Tylan 200 for this boa if you are dosing at 50 mg/kg. I believe this would more than likely be a safe dosage as tylosin has a large margin of safety. However, I would personally not dose that high and would probably go with about half of that for this boa or 0.75 cc per dose for simplicity sake with this particular antibiotic and its intrinsic safety margin. I have attached below my 2010 post that was referenced above for further information on tylosin and its usage. Please let me know if you have any other questions on this one. Thanks,

Kelly

Tylan, or tylosin, is a macrolide class antibiotic that is mainly effective against only gram positive bacteria. It has been used successfully to treat chronic RI in reptiles caused by bacteria of the genus Mycoplasma and in rare cases Streptococcus. Tylosin will usually work well only if the causative organism of the RI is Mycoplasma, otherwise it will usually be ineffective in resolving most other types of bacterial infections in reptiles. Tylosin is usually used when long term chronic RI’s are unresponsive to other antibiotic regimens as this is what is typically seen with Mycoplasma infections.

Tylosin is relatively non-toxic and has a wide margin of safety, and I have seen dosage recommendations running from 5 to 50 mg/kg body weight at 24 to 72 hour intervals between dosages. In the 1980’s I used it at 25 mg/kg per day on large burmese pythons with no toxic effects, however I would definitely not suggest that dosage. I have not seen any formal clinical studies conducted with tylosin on reptiles, but Ross, and later Jenkins, have both looked at it informally.

Most RI’s in boids are caused by gram negative bacteria species and these would require cephalosporin, fluoroquinolone, or aminoglycoside class antibiotics. These other classes of antibiotics will be much more effective unless the RI is being caused by Mycoplasma. I would recommend that a vet check any boa for which antibiotic treatment is anticipated and determine if tylosin is the appropriate antibiotic of choice, however be aware that susceptibility testing for target organisms is problematic as most of these bacteria species are present in healthy boids as well.

The standard dosage of tylosin for most boids is 20 mg/kg every 48 hours. Tylan 200 contains 200 mg of tylosin per cc, so as a rough guideline, 1 cc of Tylan 200 would be about a single dose for a 20 to 25 pound boa, and you could extrapolate that dosage to determine the proper dosage for other size boas by weight accordingly.

How well does "Liquamycin LA-200" (oxytetracyclene) stack-up to some of the other antibiotics in your opinion in treating RI's in colubrids?

Is it good at targeting most gram negative bacteria in your experience? Also, I know antibiotics are best administered SQ, but can Liquamycin be given orally and be very effective in your experience. As you know, small colubrids don't have nearly the muscle density that the larger bodied boids do and there is no going deep into say a 300 gram milksnake or a 500 gram ratsnake.

What would your regimen be on it too given either SQ or orally?

........thanks!

~Doug
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"a snake in the grass is a GOOD thing"

serpentinespecialties.webs.com

Doug,
Oxytetracycline, as with the entire tetracycline group, is considered a broad-spectrum antibiotic, and is effective against some gram negative bacterial species. However, this antibiotic group does not have great effectiveness on the bacterial species that are mainly responsible for the majority of bacterial infections in snakes. It has however been used successfully to treat other types of bacterial infections in domestic mammals and birds, and in some cases turtles. The main problem is that it is not well absorbed by snakes either orally or by injection and therefore the bioavailability is low with this group of antibiotics when used in snakes. The other problem is that it does cause some tissue damage when injected, and therefore its use by injection in small snakes should be discouraged. Doxycycline is another in this group and it has a wider spectrum of activity, and is more bioavailable, so it would be a better choice out of the tetracycline group, however you would still have the same drawbacks listed above for oxytetracycline.

I would probably only use oxytetracycline or doxycycline in those cases where susceptibility testing showed that this was a good choice against the causative organism of the infection. The only time I could see using it otherwise would be in cases where organisms of the genus Mycoplasma were the suspected or proven agent of the infection, and then only in conjunction with tylosin. It has been shown that when these two antibiotics are given together, they appear to express a synergistic effect against Mycoplasma.

There are other more effective and safer antibiotics that can be used with colubrids, specifically cephalosporin class antibiotics, ciprofloxacin, and some aminoglycosides when used carefully. Thanks,

Kelly

Thanks, Kelly....

Yes, That does pretty much correlate with other information I have researched regarding it. I used it on a large Yellow Ratsnake many years ago and didn't have any real results with it either. As you said, other types I'm sure would have done the job much better, but the oxytetracycline was all I had available to me at the time. Thankfully with my husbandry methods over the many years, there is RARELY ever a need for any antibiotic administration.

thanks again for the useful info!..

~Doug
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"a snake in the grass is a GOOD thing"

serpentinespecialties.webs.com