"A good book to get you started understanding genetics is, "genetics for herpers". The reptile and amphibian breeders guide to genetics"
Thanks for the book suggestion Scott. Maybe now I can "get started" on understanding basic reptile genetics....
Does the book go into all of these details?.......
Amphibians and reptiles skin contains three kinds of highly branched color cells called chromatophores. The chromatophores occur in three discrete layers. The top layer is generally made of xanthophores bearing yellow pigments; the middle layer includes iridophores, and the bottom layer has melanophores with black or brown melanin. In the typical green frog, light penetrates to the iridophores, which act like tiny mirrors to reflect and scatter mostly blue light back into the xanthopores above them. The xanthopores contain yellow pigments, and act as yellow filters so the light escaping to the skin surface appears green to our eyes. If a frog lacks the yellow xanthophores, blue light scatters back and the frog appears bright blue.
Iridophores do not synthesize pigments, but reflect and refract color. They contain platelets that produce a scattering effect. The real advantage to these stacks of pigment cells lies in their potential to create color changes. The animal can darken its color by moving the melanin pigment. By manipulating the three types of cells, a wide range of colors can be produced, usually extending from bright green to shades of brown and grey.
Generally xanthophores contain pteridines (synthesized) and are yellow, but they can also produce red pigments. Sometimes the top layer may contain erythrophores as well as xanthophores.
Erythrophores contain carotenoids (absorbed through diet) which produce intermediate colors like orange, reddish-orange, and yellowish-orange. The distinction is not always made, as sometimes pteridine and carotenoids are found in the same cell.
Chromatophore Subtypes - xanthophores, iridophores and melanophores contain all elements of all the chromatophore types. Thus, melanophores contain pterinosomes and the iridophore plates (called reflecting platelets), but what makes them distinctly one type or another is the degree to which they contain the other structures. Melanophores are melanophores because they contain around 99.9% melanosomes and only a small percentage of the other structures. This is important to note, because this fact is what gave rise to the single progenitor theory for chromatophres.
Melanophores - contain mostly melanosomes and are capable of two forms of pigment production. Eumelanin is brown to black and pheomelanin is orange to rust or rusty brown. Melanophores, unlike melanocytes in mammals, generally do not inject their melanosomes into keratinocytes. They are also usually able to move their melanosomes into their dendrites or into the perikaryon depending on neurohormonal stimulation. The melanins are contained within the melanosomes.
Xanthophores - contain two major pigment bodies the pterinosomes containing pteridines and vesicles that contain fats with stored carotenoids. Another class of organelle may exist in which the pteridines are converted to drosopterins and some people have suggested the name drosopterinosome. However, since drosopterins are made from pteridines, this may be a bit of a splitter attitude, and really may not be valid. But it cannot be denied that yellow pteridine rich cells occur within microns of orange or red drosopterin rich cells, so there may be something to the separation. At any rate, xanthophores can be divided into at least two subtypes.
•Yellow xanthophores - contain organelles called pterinosomes that are pterinidine rich and range from creamy yellow to orange. Since these cells are yellow to yellow orange and the term xanthophore can apply to the red xanthophores as well, there is a good argument to refer to this subtype as luteophores, but that term has yet to catch on.
•Red xanthophores (erythrophores) - pterinosomes (drosopterinosomes) are rich in drosopterins which range from orange to red and even violet. These cells are more easily seen on histology than their yellow counterparts.
Color Abnormalities:
Here is a list of color abnormality definitions so you can see why color abnormalities are a group of conditions that are problematic to name.
•RED PIGMENT
•Erythrism /Erythristic - excessive production and deposition, or distribution of red pigments (orange possibly).
•Anerythrism /Anerythristic - lack of production of pigments in the darker orange to red range.
•Hypoerythrism /Hypoerythristic - reduction in the amount of darker orange to red pigments so that the appearance of this color is largely absent except for traces or appears "washed out."
•YELLOW PIGMENT
•Xanthism / Xanthic - excessive production and deposition, or distribution of yellow pigments (orange possibly).
•Axanthism /Axanthic - lack of yellow and lighter orange pigments, depending on the point in the pigment cascade, this mutation can also cause corresponding anerythrism since erythric pigments (drosopterins) appear to come from the more yellow pteridines biochemically.
•Hypoxanthism / Hypoxanthic - reduction int he amount of yellow or lighter orange pigments so that the appearance of this color is only found in trace amounts or appears "washed out." This may also result in hypoerythrism since the red pigments appear to be made from the yellow pteridines.
•BLACK PIGMENT
•Melanism / Melanistic - excessive producution and deposition, or distribution of melanin pigments (may be orange if pheomelanin to black if eumelanin).
•Amelanism / Amelanistic - lack of melanin production. At least three basic forms are possible, though whether all forms have been observed is questionable. 1) amelanism where the chemical cascade is defected before eumelanin and pheomelanins take separate biochemical routes, resulting in a complete lack of melanin production. 2) aeumelanism - where only eumelanin production is blocked. 3) apheomelanism where only production of pheomelanins is blocked.
•Hypomelanism / Hypomelanistic - condition resulting in the reduced production of melanins. At least three types are possible by restriction of production at the initial stages of melanin production, at the eumalnin production cascade or at the pheomelanin cascade.
•IRIDOPHORE GRANULES
•Iridism / Iridistic - excessive production and deposition, or distribution of iridophore platelets (this is, as yet, only a theoretical condition).
•Aniridism / Aniridistic - (again theoretical - I have not heard this reported) lack of the formation of refractile platelets in iridophores.
•Hypoiridism / Hypoiridistic - (theoretical) reduction in the number of refractile platelets formed in iridophores.
Leukism (Leucism)
Pronunciation Problems to Ponder
Many questions have been asked of me as a herpetologist and veterinarian. One of these is the nature of leucism. First of all, it is NOT pronounced "loo-si-zm" saying that immediately identifies a person as poorly educated in scientific and medical terminology. The correct pronunciation is "loo-ki-zm." In Classical Latin the C is always pronounced like K - the so called hard C sound. You do not call a neoplasm of blood cells "loo-see-mee-ah" it is pronounced "loo-kee-mee-ah." The rule is the same for the prefix leuc- or leuk- across the board. White blood cells are pronounced "loo- ko- site" not "loose- o- site" (which incidentally, is spelled leukocyte or leucocyte with the k form being more common, but both correct). It is "loo- ko-" in the words leucoencephalomalacia and all other words with the prefix. Arrogant as it sounds, in many medical circles the mispronunciation of basic words like that makes people think of you as poorly educated and without a firm grasp of scientific or medical language. In fact, one colleague of mine once heard another doctor say "loo-sis-tic" and said "did you hear that? Where did he get his doctorate? From an online college staffed by trailer trash?" Ok, I agree that is harsh, but similar (though more tactfully expressed sentiments ) are frequently found in the halls of academia. So mispronouncing words can make people dismiss you as a rube, so make an effort not to do it.
Where does this come from? Leuc- is the Latin form of the Greek Leukos. Thus, technically any word that is spelled with the leuc- prefix can be spelled with the Greek prefix instead and spelled leuk-. An example is the word leukocyte. The Greek is used, but it is acceptable (though more rare) to spell it with the Latin to form leucocyte. In the case of leucism the opposite has become true. The Latin form has become more widespread, but the Greek is equally valid. Thus, leukism is correct. In fact, I have increasingly begun to spell it with the Greek spelling because of the pronunciation issue.
Some have suggested that the S sound is apt since it comes from Greek and is transformed into the Latin, but this is a form of grasping at straws in order to garner some reason to preserve the incorrect pronunciation. The scientific terms are based (ideally) on the Latin pronunciation. Even the scientific names of animals come from various languages (Gopherus the genus of the gopher tortoise actually comes from French), but they are "latinized." The standard Latin in science is Classical Latin. That is the Latin that was the Emperor's Latin during the Pax Romana. Another Latin did exist called the Vulgate (Vulgar Latin) which was the Latin spoken by the commoners, mostly illiterate and lower class Romans. This Latin is what ultimately spreads and becomes the common Latin after the fall of Rome, and the so called Church Latin. Think of it this way, the difference is like the difference between the Queen's English and Cockney. The ideal pronunciation in science was decided to be based on the "higher" form of Latin, Classical Latin. Thus, any C is pronounced as a C not an S. The use of an S sound is Vulgate - Vulgar Latin. So if you want to be vulgar you can be, but it is better to sound like you are educated.
Unfortunately, most people that pronounce it "loo-si-zm" are hobbyists that are poorly trained in medical terminology, if they are trained at all. Most know nothing about science beyond their high school biology and chemistry classes. It is very difficult to correct people that have formed an entire community which is equally badly educated. You fall into a form of peer pressure to be wrong. If you pronounce a word correctly when everybody else is pronouncing it wrong you are looked at as a jerk or a wierdo. Veterinarians and some herpetologists then adopt the incorrect pronunciation so they will not offend their clients.
This is what scientists and medical professionals have to combat. Peer ignorance pressure is difficult to overcome. I can remember speaking to a group of hobbyists not long ago and someone asked me a question about leukism. I corrected their pronounciation very politely, but you should have seen the looks from the whole room. I said, "I'm sorry, do you mean leukism?" The person looked a little puzzled. I continued by saying "the condition is called leukism, it comes from the Greek leukos meaning white." The whole room smiled and looked rather odd. I asked several people afterward why they looked odd. They laughed and said "everybody says 'leusism'." When I pointed out that was not correct, they replied "maybe, but if you say it like you say it, people will think you are wierd."
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"a snake in the grass is a GOOD thing" 

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