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Can I breed two great grandchildren females sired from different
studs? I want to mate a female toy poodle and a male poddle that are dedcendants of the same Mother. Can I do this without worry of Genetic problems?

>>Can I breed two great grandchildren females sired from different
>> studs? I want to mate a female toy poodle and a male poddle that are dedcendants of the same Mother. Can I do this without worry of Genetic problems?

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No, not if you don't know the bloodlines and all the genetic problems involved and what the mode of inheritance for each of them is. You need a breeder who knows the genetics of the breed to mentor you.
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Kathy Diamond Davis, author, "Therapy Dogs: Training Your Dog to Reach Others," 2nd edition, and the free Canine Behavior Series articles at http://www.veterinarypartner.com/Content.plx?P=SRC&S=1&SourceID=47

I do know the bloodlines. the Mother of both has been bred several times before each time with a different stud.

Just knowing the names in the lines is not enough. You need to know the results from the breedings within those lines and all the health issues that have been reported in those lines- from dogs that are directly in the lines as well as altered dogs in the lines.

Lines breedings can be done and are done, but you have to be incredibly careful when you do them. Line breedings tend to concentrate the problems within a line and make them more apparent. They also enhance the good qualities as well, but genetics are wierd and strange things creep up when lines get more related.
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Chelle and the rest of the crew including, but not limited to Kita and Taiko (the shiba inu wrestle maniacs), Adi (reserved and dignified tabby cat), and all 28 reptiles

You know, genetically based health issues result in dogs that are inbred and those that aren't. The worry is a result of the breeder's temperament more than anything else.

But - that being said - breeding related dogs does increase the risk of the same recessive negative alleles being inherited from both parents - resuting in a dog that expresses a disease caused by the homozygous nature of this gene.

Now - what breeders can and often are doing (Poodle breeders can be proud because much of this work was first being explored by Standard Poodle fanciers) is calculating the coefficient of inbreeding (COI). This is simply a percentage number of the degree of inbreeding. Within each breed there is an average COI. One of the goals of every single litter should be to reduce the COI, certainly below the average for the breed.

Software is available for this. Search on Google or Yahoo or whatever for "COI dog breeding software" and invest in it.

Best of Luck

My answer would be yes, HOWEVER, before you plan this breeding make sure you talk to as many breeders of this line as possible. If there are any serious health or temperament problems known to pop up in the line, I would think long and hard before undertaking such a breeding. Some lines have fewer health issues than others, and these are the best to use inbreeding or close linebreeding on.
Chances are that something unsavory may emerge from this breeding, but consider it a valuable tool. Inbreedings are a good way to discover skeletons in your bloodline's closet, and thus, it can assist you in making better, more informed breeding decisions in the future.
Inbred dogs are not less healthy or tempermentally unstable by nature unless you are breeding to unstable sire and dam or from a line which consistantly produces these traits. I recently bred a dog puppy back to his dam and so far, this has been my best litter. More vigorous than my other litters and outstanding temperaments. Time will tell but the majority of the litter seems to be potential show/working/breeding quality thus far )
If you're serious about your breeding program, you will probably have to inbreed at one time or another. JMHO.