Reptile & Amphibian Forums

I have used the holistic remedy called Ox-E drops, which is a natural anti inflammatory/antibacterial/viral & antifunfal treatment(www.nzymes.com) in the past for a dog that had a vaginal yeast infection. It worked so well the last time that when a different dog appeared to have the same problem, I immediately ordered the product again. I recieved the Ox-E Drops on June 5th, and began applying the 2% solution (1tsp of Ox-E drops to one cup filtered water as a douche & also gave it orally (1 drop per lb. diluted in 1tsp of water). On the night of June 7th, I noticed this dog was a bit lethargic, but otherise in good spirits. During the night she appeared to be in pain, panting heavily/shaking. The morning of the 8th she woke up paralyzed in the rear. I took her to the Vet immediately, who diagnosed her w/ a slipped disc. He wanted to give her electromagnetic treatments for a week w/o any pain meds. Needless to say I took her to a second Vet on Sat, the 9th. He gave her anti infmammatory & pain meds (Novox & an injection in his office - sorry, can't recall the name of it). I continued to five her Ox-E drops orally, since the website claims it can help dogs with disc problems. I've had dogs with slipped discs before, but I have never seen one deteriorate so rapidly and suffer so terribly before I took her to the Vet again on Monday, June 11th, at which time he told me her disc had ruptured & due to the extensive pain she was in, we made the decision to euthanize her. She was 3yrs old & had two first place wins in the Midwest Gundog Association's Gundog Brace field trials. She'd just whelped a litter of pups and despite that, was in great shape. We'd been running her on hare the past 2 weeks before she passed, and she never came back stiff or sore.
In the meantime, I was giving the Ox-E drops oral solution to my other 8 Beagles, for preventative health measures. On June 12th, the day after we lost our Millie, my 14 month old bitch quite suddenly became lame while in the yard. She hadn't been running or exerting herself. Just could not place any weight on her right hind leg. Again, it was off to the Vet the following day. The problem had gotten better (oddly enough, that night they did not have the Ox-E drops mixed in w/ their food as I have them an RMB meal). The limping had greatly improved, but an x-ray showed mild swelling of the joints. She was given Metacam to help with the inflammation. I chalked it up to bad luck, and crapshod timing.
Last night, while I was running my hounds in the field, I heard a clicking in the joints of one of my 20 month old males. He came back to me very, very stiff, and after some rest, is doing better this morning. I gave them Ox-E Drops in their water a few hours ago, but have not given them the more concentrated oral solution today. This afternoon, one of my 3yr old males, who dioes have a history of on/off pano, fell over while walking in the yard and could not right himself for about 30 seconds.When he did get up he was unable to place weight on his rear leg. He's been resting for about an hour and is a bit better.
I seem to be having quite the problem with inflammation problems in my hounds over the past week, when I have gone 4 years of raising multiple huntign dogs without any such incidences. One dog is unfortunate, two is a horrible coincidence, three is getting ridiculous, but four raises my suspicions. The absolute only thing that has changed with my hounds in any way whatsoever since these problems began is the introduction of the Ox-E drops. Their environment, exercize level, diet have remained the same (they are on a homecooked diet supplemented w/ raw).
I was wondering if it was possible for this product that is supposed to be an anti inflammatory to actually cause severe inflammation??? (and btw, these affected dogs were not of the same bloodline & except for the one w/ on/off Pano had no previous joint problems) I have not yet brought this to the attention of the company but plan on doing so. If anyone has ever had a negative/similar experience w/ this product, I would appreciate hearing about your experience. Thanks!

According to their website, the active component is sodium chlorite, an oxidizing agent, but they don't tell what the other 95% ( the inert ingredients) are. The symptoms you have described in your dogs can be caused by disc or cruciate problems. In theory, oxidizing agents can cause weakening in connective tissue, which is why such problems are often prevented by using antioxidents. In your particular case, I can't tell you if Ox-E drops were related to the problems.

Dr. Tobin, I cannot thank you enough for your reply! It hadn't occurred to me, but I will definitely have to inquire as to what the companiy's inert ingredients used in the product are. Again, thank you!