I don't think spiny mice can breed with fancy mice at all. Fancy mice can't even breed with regular deer mice which are their wild cousins. Also, don't house spiny mice with fancy mice either. They can carry parasites or micro-organisms that are not harmful to themselves but could be deadly to the other species.
You can tell mice are pregnant easier when they are 14 days pregnant as they start getting that lightbulb like shape as mentioned already. If you have the mouse for more than 21 days then it isn't pregnant at all. Mouse gestation is about 21 days on average.