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looking for input from BGF

repmedic Nov 19, 2003 12:54 PM

this is a post from a working dog board that i frequent. i was wondering your opinon on the subject.

Pat Coleby on Vitamin C Treatment for SNAKE BITES
Posted by TOPDOG on November 18, 2003, 11:30 pm
66.215.96.8

Early in 1930, an American, Dr Klenner, (extensive article on Vitamin C by Dr. Klenner here) did much research on the use of Vitamin C on humans. In turn a Californian Vet, Dr Wendell Bellfield, carried on the good work with impressive results on all sorts of dog ailments that are generally considered incurable or fatal. Today, in USA, there are now a significant number if Vets practicing alternative Medicine such as this.
After studying the literature, I decided that I really had nothing to lose trying Vitamin C on my own farm animals. The first one was a pony, almost moribund, whose blood was later diagnosed as having the largest amount of Tiger Snake venom the Vet had ever seen in an animal. Within 24 hours of being unable to move, and also having considerable difficulty in breathing due to pneumonia, the pony was grazing happily in its owners garden, apparently quite healthy. I only had one 30ml bottle of Vitamin C, half of what I would have liked, so I put half of the bottle into each side of the neck by intramuscular injection.
After that we treated sundry dogs, two cats and several goats including a stud buck. All recovered. A very valuable Alpaca which was being watched by its owner from her kitchen window went down to the dam to examine something. The owner, horrified, watched a large snake rise up and strike it on the nose - the worst place - and thanked her lucky stars the Vitamin C was in the fridge - not still on the shopping list. Rushing out with only 15 mls in the syringe - she injected the Alpaca before any symptoms arose. The snake had looked like a brown or a tiger, the result - happy ending.
The great advantage of Vitamin C is that anaphylaxis does not occur and the variety of snake does not matter. Vitamin C is cheap, easy to store and taking it on a hunting trip is no problem. All you need is a 20 ml syringe, some largish needles - say No 18 - and the bottle of Vitamin C. It can all be carried in a small wallet on ones belt. In between times it should be kept in the fridge. Although the stuff can be carried in Summer without deteriorating, I suggest to hunters that they get a fresh supply each Spring just to be on the safe side.
After much reading of printouts of Bellfield's and other literature, many supplied by Dr Glen Dettman, a retired pathologist who lives near Melbourne, I have tried Vitamin C on many situations. A dog in a tick coma, spider bites, dogs with Parvo, Tetanus following a terrible injury from a car, and in cases of shock - all with unfailing success.
Vitamin C can be used as crushed tablets or powder straight into the mouth in cases of sickness. From my own experience, rubbing the powder into a redback spider bite took the pain (which is incredible) our within seconds. I followed it up with 10 grams by mouth. The spread of the poison in my arm stopped and I was able to resume work within a few minutes.
The first goat I treated with Vitamin C was given a teaspoon of ascorbic acid powder (about 5 grams) every half hour for two hours, like the Alpaca, he was bitten right on the nose as I later found out. He recovered perfectly well. That was in the days before the injectable supplies were available. 50 ml bottles of Vitamin C can be obtained from some Chemists, most fodder or pet stores. Make sure the brand is 2 mls per gram and not 4 otherwise you need twice as much at twice the cost. I mentioned the size of the needles as 18 or thereabouts because the stuff can be slightly glutinous and speed is generally all important on the occasions when it is needed.
Snake venom affects the nervous system which slows down until natural functions cease and death occurs. A painful way to die. It can cause instant death but this is most unusual and I have never seen it. When a dog has been bitten, its eyes will soon appear to look all black. That is the pupils have relaxed and dilated. Since snake bite can - and usually does - occur unwitnessed, if your dog slows down and becomes lethargic or distressed, do look at the eyes at once and even if they do not show much sign get on with the injection. If by chance the fang marks are detected, (it is usually damp around the bite) rub in Vit C. Even a chewed up tablet will work. But do not waste time looking for the marks. They often only show up a few days later when the hair falls away around them.
Dogs of 30 to 50 kg will require about 10 - 15 mls* by intramuscular injection in the side of the neck. It was taught by the teaching Vet at the Veterinary College to avoid doing injections in the back legs because it is too easy to damage vital nerves there. Three quarters to 1 cm penetration is needed, and, if in doubt, get it under the skin anyway. You can repeat the treatment without risk. Vitamin C overdose results in nothing worse than diarrhoea, and anaphylaxis cannot occur. However when the dog is really sick it will allow you to do the injecting (which can sting in small animals) without objecting. If it starts to make a fuss you know that it is feeling much better, and the subsequent doses should be given as powder in the mouth. It is a good idea to give two or three backups just to make sure all the venom has been detoxified.
Pat Coleby
(Pat is a farmer who writes books on animal care and lectures widely on the subject as well as being a consultant.) Originally published in the Australian Shooters Journal.

Another article from DERRINGER JACK RUSSELL TERRIERS, Australia, and used with their permission.

Snake venom affects the nervous system, it slows it down until natural functions stop or are inadequate to support life. A dog's eyes will dilate, looking all black soon after being bitten. So if your dog appears slow, lethargic or distressed, check the eyes. The dog may have had a snake bite while out of your sight.
Our experience is that most bites appear to be not seen, leaving the dog to show signs of distress before examination shows the problem. By this time it is generally too late for conventional cures to work, or cause severe organ damage if successful.
Fang marks can be hard to find as not all bites bleed. If the strike is fresh, there will be a wet area, however, most bites are located a few days later when the hair falls out around the wound.
The big advantage of using vitamin C is that it is readily available from a variety of locations, it is easy to store, and can be carried on a hunt without any special requirements. All you need is a 50 ml. bottle of Vitamin C, a 20ml syringe, and large needles around No. 18 size. Keep it in the fridge between hunts.
Dogs of 66 lbs to 110 lbs would need 10 to 15 mls by intra-muscular injection to the side of the neck. Depth of 1/4 to 3/8 of an inch is needed. If you are worried about this, just get it under the skin at the minimum. However muscle penetration is preferred, particularly if the dog has advanced symptoms.
You can do follow up injections to ensure the venom has been detoxified. An overdose of Vitamin C does no more than give the dog diarrhea. Anaphylaxis cannot occur, and the type of snake does not matter.
You can use vitamin C tablets as the follow up if you are happy with the initial improvement. The dog by now will not be in the mood to have more needles.
The tablets can be crushed and used on the bite to detoxify the wound, but it is no replacement for the injection.
The powdered tablets can be used on humans to ease bug bites, such as bull ant or redback spider. I do not know anyone game enough to try the Vitamin C shots on themselves after a snake bite, but I guess its an option if you are desperate enough.
One case to use as an example is a Jack who was find barking under the veranda, that showed no signs of a bite when called out, and nothing was seen under the house. An hour later at dusk, the Jack was found rigid and finding it hard to breath. 5 mls was injected into the neck muscles which the dog did not feel. The owners family were all in tears and probably in need of a shot themselves.
After about 40 minutes, the Jack started to breath a bit easier, and the stiffness started to abate. Another 5mls was injected into the neck, this time she felt the needle..
About 2 hours after the first shot, the dog was on the move again, wondering what all the fuss was about. Next morning 2x1000 mg, human Vitamin C tablets were given as a backup.
We have heard of all types of animals being given this treatment successfully.

Anezka Davis
Email: jackrussellstud@ozemail.com.au
Derringer Jack Russell Terriers.
http://members.ozemail.com.au/~jackrussellstud/jackrussellstud025.htm

Replies (9)

BGF Nov 19, 2003 06:11 PM

I would view this with a great deal of scepticism. Venom proteins are nothing special, they are simply body proteins that have been recruited for use in the venom. The ancestral proteins are tweaked to make them more potent or to have a new activity. For example, the tiger snake prothrombin activator is about 85% identical to the human form but has over 1,000 times the affinity for prothrombin. If vitamin C was able to neutralise it, it would also be neutralising the natural version. This of course wouldn't be good! As far as the neurotoxins, the 3FTx are simply modified version of common cell adhesion proteins we have all through our body (including being used in the immune system). Yet again, if vitamin C actually had an effect, it would also have devastating effects upon the body. Since this isn't occuring, it is therefore unlikely its having any effect upon the venom either.

There is really only one proven and effective treatment for snake bite and that is antivenom. Suggestions of alternate therapies by non-specialists in the area (or non-clinicians entirely) could be potentially disasterous.

Also, isn't ten grams of vitamin C a massive amount even for a water soluble vitamin? Is it possible to get vitamin C hypervitaminosis?

Cheers
B
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Dr. Bryan Grieg Fry
Deputy Director
Australian Venom Research Unit
University of Melbourne

www.venomdoc.com

Rattler456 Nov 20, 2003 09:03 AM

Unless I'm mistaken ... (I'm not a doctor, nor a lawyer, nor a good candidate for a lawsuit (no deep pockets)) ... Vitamin C is one of the few vitamins that you can't OD on, any unused is passed harmlessly out of the body.... I recently read an article about a treatment for HIV related malady's that uses mega-doses of vitamin C in conjunction with some other medications that is showing amazing results.

Perhaps some doctor or our resident paramedic here on the forum would be able to elaborate further or correct me if I'm mistaken.

WK Nov 20, 2003 11:40 AM

You’re right about Vitamin C being fairly safe, even in large doses. The most likely consequence of taking a large dose of Vitamin is C is incurring a bout of “the runs”. If you are someone with subnormal kidney function, large vitamin C doses can increase your chances of developing a particular type of kidney stone. Chewing on vitamin C tabs chronically can damage your teeth because vitamin C (a.k.a. ascorbic acid) decreases saliva pH, causing leaching of calcium from teeth. People that chronically reflux stomach acid through the esophagus into the mouth show similar dental deterioration for the same reason.

There really isn’t any concrete evidence suggesting high-dose vit C is helpful in treating HIV. However, vitamin C is an antioxidant and many of the drugs used to treat HIV produce oxidant-mediated damage to body cells and tissues. This means vitamin C might be helpful in reducing the toxic effects of anti-HIV meds. This anti-oxidant effect is the only biochemical effect, as far as I know, that could possibly be of use in countering the effects of snake venom, and even this assumes that a major mechanism of venom toxin action is induction of oxidative damage. As a random example, if presynaptic neurotoxins damage nerves by causing increased intra-neuronal oxidation, huge vitamin C doses could theoretically decrease further damage. It would not be able to undo damage already done, though, so a snake-bitten terrier lying on the ground, eyes crossed, tongue lolling and hind limb twitching, would likely not be able to sit up and beg for a cookie after receiving only vitamin C.

I’ll second the statement that the only proven, significantly helpful treatment for venomous snakebite is antivenom.

Cheers,
WK

WW Nov 20, 2003 12:01 AM

(i) many snakes inject little or no venom when biting, hence a good percentage of bites are "dry" or with only mild envenomation
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WW Home

WW Nov 20, 2003 12:06 AM

>>i) many snakes inject little or no venom when biting, hence a good percentage of bites are "dry" or with only mild envenomation
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>> WW Home
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WW Home

WW Nov 20, 2003 12:04 AM

(i) snakes often inject little venom when biting, so that most bites are either dry, or show only minimal envenoming

(ii) Vitamin C is rekarkably non-toxic even at high doses.

Since alternative practitioners would probably make exactly the same claims about homeopathic remedies that are so dilute as to contain none of the supposedly active ingredients (but their memory is imprinted in the water, so that's OK... yeah right!), I would treat any claims of this nature with extreme skepticism, not to say cynicism, unless they have been performed within the framework of a rigorous scientific study.

Cheers,

Wolfgang
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WW Home

repmedic Nov 20, 2003 05:47 AM

don't get me wrong i'm with you guys on this. people get a little overboard on this stuff for their dogs, they never mention about trying it on themselves though lol. i just figured i'd get a few opinions on it. thank you very much for your input, as always.

greg

oldherper Nov 20, 2003 07:58 AM

Yeah, my guess is that (as with many other "home remedies" the patient would have recovered anyway. That's how a lot of the remedies get started...someone tries something as a remedy on a patient that would have recovered without treatment and because the patient lived, they figure the treatment must have worked....unless, of course, the treatment kills a patient that would have otherwise lived. The real danger to this kind of thing is that often real treatment is delayed or foregone while home remedies are used and a patient that could have lived with real treatment dies because of it.

Larry D. Fishel Nov 20, 2003 02:16 PM

One more thing, and the biggest reason I tend to be skeptical about a lot of home remedies: If this actually worked, SOMEONE would have ponied up the money for a clinical trial by now and become fabulously rich while putting the antivenom labs out of business.
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Larry D. Fishel
Side effects may include paralysis
and death but are generally mild.

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