While freezing/thawing does reduce the nutrients, it's still an open question whether the reduction is enough to matter.
As far as I know, freezing has no effect on the calcium and phosporus in pinkie bones. Adding extra calcium may do more harm than good. The calcium/phosphorus ratio needs to be in the right range, which it is in rodents.
OTOH, I have supplemented the diet of corn snakes with a good bird liquid multiple vitamin (A, B, C, D3, riboflavin, etc., but not minerals). Reptiles need D3, like birds, while mammals can use D2. I think extra vitamins are most helpful for fast-growing babies and breeder females. But even then I never gave more than one small drop a month. Unfortunately, the brand I've used has been discontinued, and I need to find a replacement.
Paul Hollander