My current Burmese, Boots, is a total peach. She is handled rather regularly and gets bathed twice a week, enduring countless pokes, prods, bumps, and even an accidental elbow to the puss with grace; she show no bias toward handler and accepts myself, my girlfriend, buddies who stop by, and a young nephew with no problem.
That having been said, there are a few things that cause strange behaviour in her: She used to completely freak if there was a frozen, thawed rat in her cage. I'm talking hissing, striking at anything moving beyond the glass, the whole nine yards. We learned quickly that rats were not a viable food option, and she's since moved to 1.5 lb. Guinea pigs and life is good.
Boots, like most snakes, requires some degree of shelter in her enclosure. Currently, two large silk plants provide her with cover and camouflage ... prior to installing the plants, she would exhibit stress-related behaviour when caged -- rostral rubbing, climbing, trying to dig down through the litter to China, etc.
Lastly, she is mostly potty-trained -- she very rarely voids in her enclosure. However, the one time she defecated in her cage, she went ape and started tearing up the joint. She ripped out a corner of the plastic cage-liner and hid underneath it until the offending matter was removed and she was forcibly bathed by my girlfriend. The few times she has urinated in the cage never produced the same result. Curious.
I've cared for two other Burmese over the years -- one albino and another normal-phase. The normal, Godiva, was absolutely amazing. Until her tragic early death, I swore she would be a show snake -- there wasn't a mean bone in her body. She never even so much as assumed an "S" stance or even looked at me sideways. She was a reptilian diplomat, changing ophidian opinion and dispelling myths everywhere she went. She was the Burm's Burm.
Punkin, the albino, was a different story. She was a pet-shop rescue job who had suffered multiple head lacerations ("Oh, I didn't realize that the glass fishtank we had her in had a hole in it ... guess she tried to crawl out"
, was shy one eye, and had twenty-eight rodent bites on her body. I had found her in a pet store, less than 2' long, with a fully-grown and quite alive rat in her cage. Punkin was, sadly, scrambled. She never achieved anything close to muscle composition (she was always a sort of limp noodle) and bit me three times. Each time it was the same story -- during her regular handling, she would putter around, happy-go-lucky, and then suddenly latch onto my forearm. Her one good eye would roll up toward me and she'd suddenly get this, "Uh oh ... I've done wrong" look. Then she'd release. Her temperament could only be described as unpredictable. She never seemed malicious or even angry -- and she'd tolerate marathon handling sessions -- but every once in a while her brain would hiccup and she'd bite.
Well I seem to have prattled on a bit ...
--jr