Mine will do that when she is going into shed, I took her out last night and as soon as i opened the lid of the shoe box I got a hissing greeting, i brought her over to the couch in the box,so i could clean her cage before she went into a full shed, i just let her sit there a bit, she finally came out after 5 minutes and I was able to hold her and seeing she was just blueing over. Cleaned her cage and snuggeled with her for a bit before putting her back in her cage. But we look like giants to thoise little things, go out in the safari and mingle with the elephants, then we will see from their point of view. 
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My roomates are 1BP,1BCI2corns,Rotti,3cats,desert scorpions, and snake food AKA the food chain. See my kids at: http://community.webshots.com/user/diggy415