Metabolic bone disease (MBD) cripples and eventually kills more than 75% of all Chamaeleo calyptratus (veiled chameleons) born in captivity. The juvenile form of this disease is called rickets. This disease is caused by an imbalanced diet that is either deficient in certain key nutrients, or when there is an oversufficiency of some nutrients, and when there is a lack of adequate UV-B irradiation, preferably from unfiltered sunshine. The bones either become rubbery and bend causing the front legs to look bowed, the jawbone to become misaligned and rubbery, and the casque bent, or the body metabolizes calcium from the bones causing them to become so thin they spontaneously fracture under the weight of the chameleon. Ribs often break and may partially heal, forming the kind of bumps you can detect in this chameleon.
A veterinarian can x-ray the skeleton to look for signs of other fractures and to assess bone density. In the presence of multiple fractures and poor bone density, euthanasia is the kindest course of action to end the chameleon's suffering from this painful condition. Euthanasia is also indicated in cases where the chameleon cannot feed or drink independently or cannot perch without losing it's grip and falling.
If there are no unhealed fractures and an improved diet and adequate UV-B exposure are effective in halting the progression of MBD under a veterinarian's guidance and care, spaying is advisable for females as they frequently die eggbound because they are unable to expel eggs, particularly if the pelvis has been deformed by MBD. The quality of life for a chameleon that has been deformed by MBD is usually very poor and the chameleon lives in constant fear because it is handicapped. A veterinarian can help you determine whether it would be kinder to euthanize a chameleon that force it to survive in stressful, and therefore, inhumane conditions.