` The water blisters I've seen on snakes have been bacteria colonies, and can look like blisters, or look otherwise. The cage, and especially the water, don't have to look dirty to have much bacteria present.
` I let my Anacondas soak as much as they want to, so I keep the water very acid, to inhibit bacteria. I add vinegar to the water, using a pH test kit to lower the pH to 5.0, or a little lower. The vinegar will defeat the carbonate buffer in the water for 48 hours, or so.
` Anacondas tolerate acid water very well, as much of the water in their natural habitat is quite acid. The vinegar, as a spray, along with a peroxide spray ( not mixed ) are great for spot cleaning and general disinfecting. Neither is dangerous to the snake, or you, this allows you to spot clean without removing the critters. Vinegar and peroxide are convenient to use because when you start spraying them, the snakes get out of the way.
` It's also very important to give them completely dry, warm substrate. Some of my Anacondas spend up to 90% of their time in water, with no problems.
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