As a rule, I try to pair animals that came from completely different sources, but I have no hesitation pairing siblings together if I know for a fact that their parents were completely unrelated.
About a year ago, I saw a crested gecko that had intense color, but also had a severely crooked spine. I was told by the owner that it was produced by pairing two nicely colored animals that came from the same breeder. He said that breeder had apparently only paid attention to color when pairing adults and neglected to add new blood to his line.
Another problem believed to be caused by inbreeding is small hatching size and/or weak hatchlings.
I haven't been breeding these guys long enough to tell you wether or not either of the above are true, but it makes sense to me that there's at least a little truth to both small size and deformities.
Of course, if a gecko is displaying any physical anomoly (that's not the result of an injury), regardless of it was caused by inbreeding, that's probably a gecko you want to avoid.
Having said all that, I've heard from numerous breeders that inbreeding isn't a problem unless you do it for more than 3-4 generations. The problem is, unless you buy geckos directly from the breeder, you never know how closely related their parents were.
I know there was no yes or no answer there for you, but hopefully that will give you a little insight.
-Anthony
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Anthony Caponetto
www.ACreptiles.com