Using the new Google Scholar search function, I found some interesting information on some research on hognose venom. Surprisingly, this was done over 10 years ago. Interpretation is not exactly easy, but for most of you the last sentence is the one that is most important...
Toxicon. 1992 Jul;30(7):775-9.
Effects of Duvernoy's gland secretions from the eastern hognose snake, Heterodon platirhinos, on smooth muscle and neuromuscular junction.
Young RA.
Oak Ridge National Laboratory, Health and Safety Research Division, TN 37831-6050.
Duvernoy's gland secretions (100 micrograms/ml) from the eastern hognose snake, Heterodon platirhinos, induced a neuromuscular blockade in the isolated frog sciatic nerve-gastrocnemius muscle preparation and effectively antagonized acetylcholine and histamine responses of the rat duodenum preparation. The Duvernoy's secretions (100 micrograms/ml) produced a reversible, excitatory effect in the guinea-pig ileum in vitro. Mice administered the secretions (100 mg/kg, i.p.) exhibited minor, transient signs of toxicity. These preliminary observations provide evidence for toxicity of H. platirhinos Duvernoy's gland secretions but do not warrant categorizing the potential toxicity of this species with that of proteroglyphous, solenoglyphous, or the more venomous opisthoglyphous species.
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