I'm not sure to which toxins you're referring, but if kept clean I'd imagine the toxin level wouldn't be different of that in substrate. also, yes you do need to clean more frequently, but a water filter reduces this need, and it's MUCH easier to clean a tank full of water and gravel than a tank full of damp coaconut fiber. I made the switch because the eco earth would always be stuck to my pacman's eyes, nostrils, etc. It was just a drag to switch the substrate all the time and if kept at a recommended moisture level, eco earth WILL mold and also attract gnats and mosquitos in my experience. My frogs have burrowed themselves into the gravel (somehow, I have no idea how) I've heard of terrestrial frogs thriving for years on simply wet paper towels that are changed every day. I don't know how true that is though...