I would be careful in housing them together. It makes for a tough situation with having to move them. Just be careful that you have enough room to move about without getting tagged. In theory snakes in the same genus can reproduce. Ie, bitis species are naturally found crossed in the wild (rhino X gaboon, gaboon X puff adder, etc). Rattlesnakes den with other snakes, and are pretty good together, but there is always more risk having 2 snakes together over one.
When working with the animals be sure you know where they both are, and remove them (or close off the section of the enclosure) from the enclosure prior to cleaning or other routine things. 2 big buzztails in one little cage is a harsh task to handle. The strike range takes a good bit of the enclosure, and with two that leaves even less room for error!
As for venom, crofab would still apply, as it is now formulated to more effectively treat the type A venom produced by the mojave rattlesnake. It won't be nearly as effective in treatment as some species, but it is still used.
My guess is if anything the venom would have a lower toxicity, while exhibiting traits of both venom compositions.
You will find naturally occuring hybrids, it happens...and your rattlesnake should take to nearly any comprable rattler of the opposite sex. I am not saying it is a good or bad idea, but entirely possible to do.
Best of luck, and be safe!
-Steve Clark